I don't watch the show, but my wife as watching it last night when I came home from work.
Mark's scheduled a gender reassignment surgery for Daniel (who now calls himself Donna). Donna's wife Vicky tells Meredith she originally left when Daniel said he wanted to become a woman, but she came back. In doing the tests before the surgery, they discover that the hormones Donna has been taking have given her breast cancer. She decides she still wants to go through with the surgery, even if it means dying. Vicky leaves again, but then comes back. "She's my best friend," she tells Meredith.
Meredith and Vicky were talking (above) about Donna. My wife kept looking over at me. "What?"
Just that my online and enfemme name is Donna. The TS on the show took the name Donna. So,whenever Donna was mmentioned, my wife would look over at me. Some SO's worry their CDing partner will transition, and the transitioning Donna on the show had my wife thinking about it again.
